Biomarkers Within The CSF Locate Brain Damage In Ischemic Stroke Patients

Ischemic injury to the central nervous system (CNS) causes cellular activation and disintegration, causing the release of specific proteins known as biomarkers into the cerebrospinal fluid (CSF). A study into the concentrations of several known biomarkers including: myelin basic protein (MBP), glial fibrillary astrocytic protein (GFAP), the calcium-binding protein S100B, and neuron-specific enolase (NSE) was conducted in ischemic stroke patients. The concentrations of these proteins in the CSF were related to: stroke severity, stroke location and stroke outcome. Some of the interesting results drawn from the study showed MBP is a marker for infarct location and GFAP/S100B correlate with stroke severity and outcome.

The study has not yet been published, but a review is available online at: www.Pubmed.gov